Ponce de Leon is an unincorporated community in northeastern Stone County, Missouri, United States, about 30 miles (50 km) south of Springfield. It is part of the Branson, Missouri Micropolitan Statistical Area.
The community is located on the East Prong Goff Creek which is a tributary of the James River about three miles to the west. Missouri Supplemental Route V passes through the village which lies at an elevation of 1100 feet. Spokane in Christian County lies about three miles to the east on US Route 160. Branson lies about 25 miles to the south.
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