Mission is a city in Todd County, South Dakota, United States, within the boundaries of the Rosebud Indian Reservation. The population was 1,182 at the 2010 census.
Mission is home of the Sinte Gleska University. It is the largest incorporated community in the county, but is smaller than the unincorporated community of Rosebud, the capital of the Rosebud Sioux Tribe.
It is named for one of the many missions established by religious groups in the late 19th century to educate and assist the Sicangu Lakota (Rosebud Sioux) and other Native American people. The major economic center of the county, it is located at the junction of US-83 and US-18. The city contains part of the Oyate Trail, the headquarters of the Todd County School District, Cherry-Todd Rural Electric Cooperative, and various federal/tribal agencies.
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