Holtsville is a hamlet and census-designated place (CDP) in Suffolk County, New York, United States. The population was 19,714 at the 2010 census.
Holtsville is mainly in the Town of Brookhaven, while the southwest portion is in the Town of Islip. An IRS Processing Center is located in Holtsville.
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The community is very quiet. It is a cross sector of young old and middle-aged residents. The shops and stores are a good distance from the houses hence peace and quiet.