Sycamore is an unincorporated community in Greene County, Pennsylvania, United States. The community is located along Pennsylvania Route 18 4 miles (6.4 km) west-northwest of Waynesburg. Sycamore has a post office with ZIP code 15364, which opened on April 25, 1878.
William J. Ely (1911-2017), United States Army general and writer was born in Sycamore.
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